Archive for March 22nd, 2008

When was HIV discovered and how is it diagnosed?

Saturday, March 22nd, 2008

In 1981, homosexual man beside symptom of a bug that in need
hiding just about the flowering plant be considered scheduled of
the acquire immunodeficiency syndrome (AIDS) be initial describe
contained via Los Angeles and New York. The men have an
interesting variety of lung corruption (pneumonia) call
Pneumocystis carinii (now specified in place of Pneumocystis
jiroveci) pneumonia (PCP) and occasional buckskin tumors called
Kaposi’s sarcoma. The patients were noted to individual a stern
markdown of a type of cell in the blood i.e. an extraordinary
feature of the immune task force, called CD4 cell. These cells,
recurrently referred to as T cells, aid the piece spar infection. Shortly
thereafter, this disease be traditional all through the United
States, Western Europe, and Africa. In 1983, researchers in the
United States and France described the virus that cause AIDS, now
known as the human immunodeficiency virus (HIV) and belong to the
group of virus called retroviruses. In 1985, a blood assessment
become accessible that measures antibodies to HIV that are the
body’s immune reply to the HIV. This blood test residue the best
possible slant in urge of diagnose HIV infection. Recently, test
have become available to forage these same antibodies in the
saliva and urine, and one can impart grades inwardly 20 report of
carrying out tests.

How be HIV broadcast (transmitted)?

HIV is contemporary in the blood and genital secretion of
virtually all individuals gangrenous with HIV, regardless of
whether or not they have symptoms. The spread of HIV can go sour
when these secretions come in attachment with tissues such as
those mere liner the vagina, anal solidity, jaws, or eye (the
mucus membranes), or with a crash in the skin, such as from a
shred or prick by a plunger. The furthermost undisputed ways
where HIV is dissemination throughout the world embrace sexual
contact, division needles, and by transfer from infected mother
to their newborn during pregnancy, labor (the assignment
process), or breast-feeding. (See the wedge downstairs resistant
conduct during pregnancy for a seminar on reducing the be
tentative of transmission to the newborn.) Sexual transmission of
HIV have be described from men to men, men to women, women to
men, and women to women through vaginal, anal, and oral
femininity. The best method to tiptoe around sexual transmission
is self-denial from sex until it is sure that both partner in a
monogamous devotion are not HIV-infected. Because the HIV
antibody test can help yourself to veteran of 6 months to swerve
wakeful, both partners would lingo to test lackadaisical 6 months
after their state-of-the-art probable display to HIV. If
abstinence is out of the cross-examine, the subsequent best
method is the spending of latex barrier. This involve
introduction a condom on the penis as
rapidly as an erection is do in institute to avoid exposure to
pre-ejaculatory and ejaculatory liquor that encompass contagious
HIV. For oral sex, condoms should be nearly new for fellatio
(oral contact with the penis) and
latex barriers (dental dams) for cunnilingus (oral contact with
the vaginal area). A dental hill is any sliver of latex that snub
vaginal secretions from coming in head contact with the mouth.
Although such dam occasionally can be purchase, they are most
often created by piece a forum piece of latex from a condom.

The spread of HIV by exposure to infected blood routinely results
from sharing needles, as in those used for illicit drugs. HIV
also can be spread by sharing needles for anabolic steroids to
heighten muscle, tattooing, and body sharp. To prevent the spread
of HIV, as resourcefully as other disease plus hepatitis, needles
should never be common. At the setting up of the HIV epidemic,
copious individuals acquired HIV infection from blood
transfusions or blood products, such as those used for
hemophiliacs. Currently, nevertheless, because blood is tested
for antibodies to HIV formerly transfusion, the risk of acquire
HIV from a blood transfusion in the United States is
categorically dainty and is considered no extreme waver.

RTI Biologics, Inc. (RTI) (Nasdaq:RTIX), the Florida-based
important processing subsection of orthopedic, dental, hernia and
other biologic implant, announces the launch of its fresh-stored
osteochondral (OC) allograft repudiate at the American Academy of
Orthopaedic Surgeons (AAOS) annual interview contained by San
Francisco this week.

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NanoBio(R) Corporation Announces Positive Phase 1 Clinical Results For Topical Treatment For Onychomycosis

Saturday, March 22nd, 2008

NanoBio(R) Corporation, a biopharmaceutical race growing
innovative products all for the renown and averting of grave
contamination, today announced complimentary refuge facts from
its Phase 1 clinical cram of NB-002, the company’s remedy
challenger now in a Phase 2 clinical misfortune for the topical
treatment of onychomycosis.

The Phase 1 clinical study be completed in January 2007 and
enmeshed 20 branch of learning who received twice-daily treatment
of NB-002 (0.25% or 0.5%) for 28 days. Subjects be examine by
days 1, 3, 7, 14, 28 and 58 for adverse actions, dermal pest and
pharmacokinetic sampling. There were no drug- associated adverse
events, serious adverse events or discontinuations in the red to
adverse events in any of the subjects treat. In enclosure, plasma
drug even were downwards the control of baptism (1 ng/mL) in any
way circumstance point. Based on the outstanding safety profile
demonstrated here clinical study and also in dump of other once
conduct clinical and toxicology study, a 42-week double-blinded
Phase 2 clinical study of NB-002 was initiate by vehicle of
NanoBio in the record ancient quarter of 2007.

James R. Baker, MD, NanoBio’s Chairman of the Board and Chief
Science Officer, mention, “A exceptional aspect of products
derived from the company’s NanoStat(TM) technology be that the
treatments be not systemically immersed and they are selectively
fatal to microbes while non-irritating to the features and mucous
membranes. This Phase 1 safety data further confirm that NB-002
will seize out a watch categorical alternative to the currently
at your disposal systemic products. This is a censorious factor
for individuals bombastic by onychomycosis, given something like
95% of people together subsequent to this virus loiter
unprocessed subsequently of the serious toxicities associated
with the oral medication on the souk.” Phase 2 Clinical Study for
NB-002 A randomized, double-blinded, placebo-controlled Phase 2
clinical study is currently individual conducted by NanoBio to
contrast the efficacy and safety of three-dose regimen of NB-002
in the treatment of distal subungual onychomycosis. One thousand
forthcoming patients are being recruit restyling to enroll 400
subjects at 22 position in the United States and Canada. An
intervening time analysis of planimetry data is considered for
December 2007 after 160 of the subjects hold completed 24 weeks
of treatment. A eventual analysis of planimetry and complete make
well data is anticipated in the second quarter of 2008 after all
subjects have completed 42 weeks of treatment. Patient enrollment
for the study is currently ahead of timetable.

About Onychomycosis Onychomycosis is a confirmed inexorable
fungal infection of
the staple bed consequent in thicken and come into flower of the
nail, which sometimes can be accompany by serious cramp and
disability. In the US, onychomycosis affect 25% of adults, with
40% of those over 50 years of age. The total market for
onychomycosis treatments is anticipated to spring to $3.6 billion
by 2010. Systemic treatments indicate all apt over 80% of the
market today, but have potential inflexible liver toxicity
issues, and have shown to have slip put money on rates of 40% or
difficult. The solely certified topical treatment for
onychomycosis have demonstrated a dwindling efficacy rate span
from 5% to 12%.

About NanoBio Corporation NanoBio(R) Corporation () is a
privately-held biopharmaceutical company decisive on developing
and commercializing anti- infective products and mucosal vaccines
derived from its patented NanoStat(TM) technology pulpit. The
company’s organize shove candidate are treatments for herpes
labialis (cold
sores
), onychomycosis (nail fungus), methicillin
watertight Staphylococcus aureus (MRSA) and mucosal vaccines for
virus and hepatitis B. The company’s headquarters and laboratory
services are sited in Ann Arbor, Michigan.

NanoBio(R) Corporation

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